The world of aesthetic medicine is always evolving, and one of the most exciting recent developments is the arrival of Letybo® (letibotulinumtoxinA-wlbg) — a new FDA-approved neuromodulator that's generating buzz in the aesthetics community. At Remedy+ Hair Restoration & Medical Spa in Grand Rapids, Michigan, we stay at the forefront of innovation to bring our clients the latest and most effective treatments available.
What Is Letybo®?
Letybo is an injectable neuromodulator — in the same family as BOTOX® Cosmetic, Dysport, Xeomin, and Jeuveau. It's manufactured by Hugel Inc., a South Korean biopharmaceutical company, and has been widely used internationally (under the brand name Letybo and Botulax) for years before receiving FDA approval for the U.S. market.
Like other neuromodulators, Letybo works by temporarily blocking nerve signals to targeted facial muscles, reducing their contraction and smoothing dynamic wrinkles — the lines that form when you make facial expressions like frowning, squinting, or raising your eyebrows.
Letybo is FDA-approved for the temporary improvement in the appearance of moderate to severe glabellar lines (the "11s" or frown lines between the eyebrows) in adults. As with other neuromodulators, experienced providers often use it off-label in other areas such as crow's feet, forehead lines, and more.
What Makes Letybo Different?
With several neuromodulators already on the market, you might wonder what sets Letybo apart. Here are some key differentiators:
High Purity
Letybo is produced using a proprietary manufacturing process that results in a highly purified botulinum toxin type A product. The purification process removes complexing proteins, which may contribute to a lower risk of developing resistance (antibodies) over time.
Proven Track Record
While new to the United States, Letybo has been used in over 50 countries worldwide and has a substantial safety and efficacy track record. Millions of treatments have been performed internationally, providing a robust body of real-world evidence.
Competitive Pricing
As a newer entrant to the U.S. market, Letybo may offer competitive pricing compared to established brands, making neurotoxin treatments more accessible to a broader range of patients.
Quick Onset
Some providers and patients have reported rapid onset of results with Letybo, with some noticing effects within 2-3 days. However, as with all neuromodulators, full results typically develop within 7-14 days.
How Does Letybo Compare to BOTOX®?
Both Letybo and BOTOX® Cosmetic are botulinum toxin type A products that work through the same mechanism. Here's how they compare:
- Active ingredient: Both contain botulinum toxin type A, though they differ in their specific formulations and manufacturing processes
- FDA approval: BOTOX has been FDA-approved since 2002 for cosmetic use; Letybo is the newest FDA-approved neuromodulator
- Efficacy: Clinical trials for Letybo demonstrated non-inferior efficacy compared to BOTOX for the treatment of glabellar lines
- Duration: Both typically last 3-4 months, though individual results may vary
- Dosing: Your provider will determine the appropriate dosing based on the product used, your facial anatomy, and your goals
At Remedy+, our experienced injectors — including Terry Selgo, RN (Master Injector with 21+ years of experience) — can help you determine which neuromodulator is the best fit for your needs and goals.
What to Expect During Letybo Treatment
The Letybo treatment experience is similar to other neuromodulator treatments:
Consultation
Your provider will evaluate your facial anatomy, discuss your concerns and goals, and determine the appropriate treatment areas and dosing. This is also the time to discuss your medical history and any medications you're taking.
Treatment
The injection process takes approximately 10-15 minutes. Your provider will use fine needles to inject small amounts of Letybo into the targeted facial muscles. Most patients describe the sensation as a slight pinch. Ice or a topical numbing agent can be applied if desired.
After Treatment
- Return to your normal activities immediately
- Avoid lying down for 4 hours after treatment
- Avoid strenuous exercise for 24 hours
- Avoid facial massages and facials for 2 weeks
- Results begin to appear within 2-7 days, with full effect at 2 weeks
Who Is a Good Candidate for Letybo?
Letybo is ideal for adults who:
- Want to reduce the appearance of moderate to severe frown lines (glabellar lines)
- Are interested in trying a newer neuromodulator option
- Have previously used BOTOX or other neuromodulators and are open to alternatives
- Are first-time neurotoxin patients looking for a proven, effective treatment
- Want natural-looking results with zero downtime
Letybo is not recommended for those who are pregnant or breastfeeding, have a known allergy to botulinum toxin products, or have certain neuromuscular disorders. Your provider will review your candidacy during consultation.
Combining Letybo with Other Treatments
Like BOTOX, Letybo works beautifully as part of a comprehensive aesthetic treatment plan:
- Dermal Fillers: While Letybo addresses dynamic wrinkles (from muscle movement), fillers restore volume. Together, they provide comprehensive facial rejuvenation
- SKINVIVE: Improve overall skin quality and hydration while Letybo smooths wrinkles
- HydraFacial: Maintain glowing, healthy skin between neuromodulator treatments
- Chemical Peels: Address surface-level concerns like pigmentation and texture alongside wrinkle reduction
Why Choose Remedy+ for Neuromodulator Treatments?
Choosing the right provider for injectable treatments is crucial. At Remedy+:
- Our injectors have years of specialized training and continued education in neuromodulators
- Terry Selgo, RN is a Master Injector and Allergan Medical Institute Faculty & Trainer with 21+ years of experience
- We're one of only ten practices in Michigan to receive the Allergan Aesthetics Top Growth Achievement Award
- We focus on natural-looking results that enhance your features without changing who you are
- We offer multiple neuromodulator options so you can choose the best product for your needs
Ready for a Refreshed Look?
Whether you're curious about Letybo or want to learn about all your neuromodulator options, Remedy+ in Grand Rapids is here to guide you. Our expert team will help you make an informed decision and achieve the refreshed, natural look you're after.
Book your consultation today at our online booking portal or call (616) 214-7228.